In a collaborative study (Philadelphia, Graz and Berlin), the group of Michael Schupp discovered a yet unknown function of the tumor suppressor p53 in food intake-regulated gene expression. p53 is a well described tumor suppressor that can translate cellular stress in senescence, apoptosis, and cell cycle arrest. This study found that p53 coordinates the switch to catabolic metabolism in several investigated tissues in order to adapt to food withdrawal. These findings could point towards a link between the regulation of p53 activity by food intake and the development of certain carcinomas. The publication also contains comprehensive gene expression profiles of adipose tissue, muscle, and adipose tissue from fed and fasted mice.
Schupp M, Chen F, Briggs ER, Rao S, Pelzmann HJ, Pessentheiner AR, Bogner-Strauss JG, Lazar MA, Baldwin D, Prokesch A., Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues., BMC Genomics. 2013 Nov 5;14:758.
Here you find the publication in pubmed.
Back to Overview